雌雄激素受体在良性前列腺增生组织中的表达

Expression of estrogen receptors and androgen receptors in benign prostatic hyperplasia prostate

目的研究雌激素受体(ER)和雄激素受体(AR)在良性前列腺增生组织的表达,探讨雌雄激素受体与良性前列腺增生(BPH)的关系。方法采用免疫组织化学法检测80例良性前列腺增生患者(60-80岁)和40例正常前列腺对照组中ER和AR表达。结果 60-70岁组前列腺组织中ER和AR表达阳性率显著高于对照组(ER:P=0.010,AR:P<0.000 1),70-80岁组前列腺组织中ER表达阳性率显著高于对照组(P=0.022),而AR表达阳性率与对照组比较没有统计学差异(P=0.108)。ER和AR表达阳性率两组间比较无统计学差异(ER:P=0.745,AR:P=0.055)。结论 ER和AR在BPH组织中高表达可能促进了BPH的发生。

Objective To investigate the expression of estrogen receptors（ER） and androgen receptors（AR） in benign prostatic hyperplasis（BPH） and to explore the relationship between estrogen receptors（ER） /androgen receptors（AR） and benign prostatic hyperplasis（BPH）.Methods Eighty patients with benign prostate hyperplasia aged 60-80 years and 40 controls with normal prostate were enrolled in this study.The levels of ER and AR were detected by immunohistochemical method.Results The positive staining rates of ER and AR in patients with 60-70 years old were significantly higher than those in controls（ER：P=0.010,AR：P0.000 1）.The positive staining rate of ER in patients with 70-80 years old were significantly higher than that in controls（P=0.022）.The positive staining rate of AR in prostate tissue showed no difference between the patients with 70-80 years old and the controls（P=0.108）.The positive staining rates of ER and AR in two groups showed no statistical difference（ER：P=0.745,AR：P=0.055）.Conclusion The high expression of ER and AR in tissues of benign prostatic hyperplasia may promote the occurrence of BPH.