声触诊组织定量技术诊断慢性移植肾肾病的初步应用

Initial application of virtual touch tissue quantification in diagnosis of chronic allograft nephropathy

目的探讨声触诊组织定量（virtual touch tissue quantification，VTQ）技术在慢性移植肾。肾病（chronic allograft nephropathy，CAN）检测中的应用价值。方法选择48例移植肾功能正常患者及50例CAN患者，分别对移植肾行彩色多普勒及VTQ检查，并对检查结果进行对比分析。结果CAN组和移植肾功能正常组之间VTQ值差异有统计学意义（P〈0．05）。用ROC曲线分析阈值，当VTQ值≥2．51m／s时，诊断CAN的敏感性、特异性、阳性预测值、阴性预测值分别为76．0％、52．1％、60．3％、65．7％，诊断准确度为62．2％。结论VTQ技术可定量反映移植肾皮质的弹性变化，测值稳定，可重复性强，能够用于监测移植肾功能变化及早期诊断CAN。

Objective To investigate the feasibility of virtual touch tissue quantification（VTQ） for the assessment of chronic allograft nephropathy（CAN）. Methods 48 patients with normal renal function and 50 patients with CAN were checked by color Doppler and VTQ technique. All the results were compared between two groups. Results Mean VTQ-values were significantly different between the two groups（ P〈0.05）. ROC curve displayed that VTQ value of 2.51 m/s could be used to diagnose CAN, the sensitivity, specificity,positive predictive value and negative predictive value were 76.0% ,52.1% ,60.3% and 65.7%, respectively. The diagnostic efficiency was 62.2 %. Conclusions Parenchymal stiffness measured by VTQ is stable and repeatable, which can be used to diagnose patients with CAN and to monitor renal function.