101例新生儿高胆红素血症对肌酸激酶同工酶活性影响的研究

Influence of Neonatal Hyperbilirubinemia on CK-MB Enzyme Activity: a Study of 101 Cases

目的探讨新生儿高胆红素血症对肌酸激酶同工酶（CK-MB）活性的影响。方法选择顺义区妇幼保健院新生儿科2011年9-12月共收治的101例新生儿高胆红素血症患儿,根据胆红素测定值分为高胆Ⅰ组（〈256.5μmol/L）,高胆Ⅱ组（256.5~307.8μmol/L）,高胆Ⅲ组（〉307.8μmol/L）。监测三组治疗前后的CK-MB值,并进行t检验对比分析。结果入院时检测三组之间CK-MB值差异无统计学意义（P〉0.05）;高胆Ⅲ组经治疗后CK-MB值下降的效果显著（P〈0.05）。结论新生儿高胆红素血症对心肌无明显的损害作用。

Objective To explore the effect of neonatal hyperbilirubinemia on CK-MB enzyme activity.Methods One hundred and one newborns with neonatal hyperbilirubinemia selected from Neonatal Department of Maternal and Child Health Hospital of Shunyi District from September to December in 2011 were enrolled in this study.They were divided into three groups according to the serum bilirubin concentrations： hyper-bilirubin group I（256.5 umol/L）,hyper-bilirubin group II（256.5~307.8 umol/L） and hyper-bilirubin group III（307.8 umol/L）.Before and after the treatment,we monitored enzyme CK-MB values of the three groups,and then compared and analyzed by t test.Results No statistically significant difference was found in enzyme CK-MB values among the three groups at the time of admission（P0.05）.But enzyme CK-MB value of hyper-bilirubin group III was significantly decreased after the treatment（P0.05）.Conclusions There is no significant myocardial damage in neonatal hyperbilirubinemia.