64排螺旋CT灌注成像对前列腺癌的诊断价值研究

Study on Diagnostic Value of 64-multidetector Spiral CT Perfusion Imaging in Prostate Carcinoma

目的探讨64排螺旋CT灌注成像对前列腺癌(PCa)的诊断价值。方法选择2006年8月-2010年5月张家口市第一医院确诊的前列腺癌患者62例,另选择正常前列腺15例为对照组。两组均行64排螺旋CT灌注成像技术检查,对比两组灌注参数之间的差异。结果对照组正常前列腺中央带和周围带的CT灌注参数比较,中央带明显高于周围带(P<0.05)。正常对照组(周围带)和PCa组的CT灌注参数比较,PCa组的BF、BV、PS明显高于对照组(周围带)(P<0.05),MTT、TTP值明显小于对照组(周围带)(P<0.05)。对照组TDC曲线呈缓升-平台型,PCa组TDC曲线呈速升-缓降型。结论 64排螺旋CT灌注成像对PCa具有重要的诊断价值,其中BF、PS、TTP对PCa的评价意义最大,能更准确反映肿瘤的血管生成,可以作为临床诊断PCa的有效普查方法。

Objective To explore the value of 64-multidetector spiral CT perfusion imaging in diagnosis of prostate carcinoma（PCa）.Methods Sixty-two patients with PCa confirmed by the First Hospital of Zhangjiakou City from August 2006 to May 2010 were selected as PCa group,and another 15 healthy individuals were served as the control group.64-multidetector spiral CT perfusion imaging was performed on all objects of the study.The differences in the perfusion parameters of the two groups,including mean blood flow（BF）,blood volume（BV）,time to peak（TTP）,mean transit time（MTT）,capillary permeability-surface（PS）,time-density curve（TDC） were documented and compared.Results In the control group,the perfusion parameters of the central zone were significantly higher than those in the peripheral zone（P0.05）.Compared with the perfusion parameters of the peripheral zone of the control group,BF,BV and PS of Pca group were significantly higher than those in the control group（P0.05）,while TTP and MTT were significantly less than those in the control group（P0.05）.Time-density curve of the control group showed a slow-rise toward plateau pattern,but that of Pca group presented a rapid-rise and slow-descending pattern.Conclusions 64-multidetector spiral CT perfusion imaging has an important value in diagnosis of Pca;BF,PS and TTP have a significant meaning in the evaluation of Pca,which can reflect tumor angiogenesis accurately.It can be used as a valuable technique in the clinical diagnosis of prostate cancer.