摘要
随着片剂生产工业的发展,对多功能性辅料的要求特别是对流动性和可压性的要求也越来越高。复合辅料是2种或是多种已有辅料经过一定的处理得到的亚微颗粒,所有辅料各取所长、优势互补。这种多功能复合辅料显著的减少了片剂中的辅料数量。文章介绍直接压片(direct compression,DC)复合辅料的优势、局限,例举了已经上市的DC辅料及其应用前景。
With the advancement of tablet manufacturing process,the demand of excipients with improved functionalities,mainly in terms of flow and compression properties,has increased.Coprocessed excipients are a mixture of two or more existing excipients at subparticle level,offer substantial benefits of the incorporated excipients and minimize their drawbacks.These multipurpose excipients have dramatically reduced the number of incorporating excipients in the tablet.The potential advantages and limitations of coprocessing and coprocessed excipients,various coprocessed excipients for direct compression available in the market and the prospects of coprocessed excipients were discused in this review.
出处
《药物生物技术》
CAS
CSCD
2012年第2期177-180,184,共5页
Pharmaceutical Biotechnology
关键词
片剂
直接压片
复合辅料
应用
前景
Tablet
Direct Compression
Functional excipient
Application
Prospect
