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成纤维细胞生长因子受体1在乳腺癌中的表达及意义 被引量：3

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摘要 国外的研究结果显示在部分乳腺癌中成纤维细胞生长因子受体1（FGFR1）存在过度表达，约10％的乳腺癌中FGFR1的过表达与不良预后有关。但国内关于FGFR1在乳腺癌中表达的临床研究较少。本研究旨在探讨FGFR1在乳腺癌中的表达及其与临床病理学参数的关系。
作者 李庆霞 张炎 王娟 张明 潘海燕 苗军程
机构地区 河北省人民医院肿瘤一科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2012年第5期814-814,共1页 Chinese Journal of Experimental Surgery
关键词 成纤维细胞生长因子受体1 乳腺癌 FGFR1 临床病理学参数 过度表达 不良预后 临床研究 过表达
分类号 R737.9 [医药卫生—肿瘤]
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参考文献3

  • 1Theillet C, Adelaide J, Louason G, et al. FGFR1 and PLAT genes and DNA amplification at 8p12 in breast and ovarian cancers. Genes Chromosomes Cancer, 1993,7 : 219-226.
  • 2Garcia MJ, Pole JC, Chin SF, et al. A1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. Oncogene, 2005,24 :5235-5245.
  • 3Turner N, Pearson A, Sharpe R, et al. FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res ,2010,70:2085- 2094.

同被引文献30

  • 1Turner N,Pearson A,Sharpe Rvet al. FGFR1 amplification drives en-docrine therapy resistance and is a therapeutic target in breast cancer [J]. Cancer Res,2010, 70(5) :2085-2094.
  • 2Weiss J .Sos ML,Seidel D, et al. Frequent and focal FGFR1 am-plification associates with therapeutically tractable FGFR1 de-pendency in squamous cell lung cancer[J]. Sci Transl Med , 2010, 2(62) :62-93.
  • 3Tsimafeyeu I, Demidov L, Stepanova E, et al. Overexpression of fibroblast growth factor receptors FGFR1 and FGFR2 in renal cell carcinoma[J]. Scand J Urol Nephrol,2011,45(3) :190-195.
  • 4Elbauomy Elsheikh S, Green AR, Lambros MB, et al. FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridi-sation analysis[J]. Breast Cancer Res, 2007 ,9(2) : 23.
  • 5Tenhagen M, van Diest PJ, Ivanova lA, et al. Fibroblast growth factor receptors in breast cancer: expression, downstream effects, and possible drug targets [J]. Endocr Relat Cancer, 2012,19(4):115-129.
  • 6Jang MH, Kim EJ .Choi v, et al. FGFR1 is amplified during the progression of in situ to invasive breast carcinoma [J]. Breast Cancer Res,2012,14(4) :115-127.
  • 7Spears M,Oesterreich Sv Migliaccio I.et al. The p160 ER co-reg-ulators predict outcome in ER negative breast cancer[J]. Breast Cancer Res Treat,2012,131(2): 463-472.
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  • 9Song JM, Lu M, Liu FF, et al. AlB1 as an independent prognostic marker in hepatocellular carcinoma after hepatic resection[J]. J Gastrointest Surg,2012,16(2) :356-360.
  • 10Torres-Arzayus MI. Zhao J, Bronson R, et al. Estrogen-depend-ent and estrogen-independent mechanisms contribute to AIB1- mediated tumor formation[J]. Cancer Res, 2010,70 (10): 4102- 4111.

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中华实验外科杂志
2012年 第5期

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