乳腺乳头状癌的临床病理特征和分子免疫表型

Clinicopathological features of papillary carcinoma of breast and molecular immunophenotypes

目的探讨乳腺乳头状癌的临床病理特征、分子免疫表型及预后。方法对320例乳腺乳头状癌手术切除标本的病理切片进行观察和免疫组织化学染色，结合临床资料进行统计学分析。结果导管内乳头状癌5年总牛存率（95．38％比83．90％）及无瘤生存率（92．31％比79．66％）均高于浸润性乳头状癌。浸润性乳头状癌分属于5个分子亚型，其中Lumina—A型5年生存率（91．43％）高于Her-2（71．43％）和三阴性型（68．42％），差异均有统计学意义（P〈0．05）。结论乳腺浸润性和非浸润性乳头状癌有不同的临床病理学特征，浸润性乳头状癌的分子表型也具有重要意义。

Objective To explore the clinieopathologieal features, molecular immunophenotypes and prognosis of papillary carcinoma of breast. Methods All the 320 cases of papillary carcinoma of breast were analyzed for clinieopathological and molecular features. Results The 5-year overall survival rate of ductal papillary carcinoma （95.38%） and 5-year disease-free survival rate （92. 31% ） were higher than those in invasive papillary carcinoma （83.90% and 79.66% respectively）. Luminal A subtype had the highest 5-year overall survival rate （91.43 % ）. Conclusion Biologic behaviors of duetal papillary carcino- ma are more favorable than those of invasive papillary carcinoma. Luminal A-positive tumors have a better prognosis.