细胞因子信号转导抑制因子3的研究进展

Research Advances in Suppressor of Cytokine Signaling 3

细胞因子信号转导抑制因子3(SOCS-3)是近年发现的一类新型细胞因子信号传导抑制分子,为SOCS家族的主要成员之一,主要参与酪氨酸蛋白激酶/信号传导子和转录激活子信号传导途径的负反馈调节,不仅参与炎症反应,同时与氧化应激、细胞损伤、凋亡等密切相关。SOCS-3作为SOCS家族中的一员,与动脉硬化、肥胖、糖代谢、胰岛素抵抗、瘦素、肿瘤、哮喘、风湿性疾病等关系密切,SOCS-3有可能成为这类疾病的一个治疗性靶标。

Suppressor of cytokine signaling（SOCS） 3,a novel type of cytokine signal transduction inhibitory molecules in family of SOCS,is mainly involved in Janus protein tyrosine kinase/signal transducer andantivator of transcription signaling pathway negative feedback regulation.It is involved in inflammation,oxidative stress,cell damage,and apoptosis.Meanwhile,it is closely related to atherosclerosis,obesity,glucose metabolism,insulin resistance,leptin,cancer,asthma,and rheumatic diseases.Therefore,SOCS-3 may become a therapeutic target of these diseases.