有暴力行为男性精神分裂症患者执行功能研究

Study on executive function of male schizophrenic patients with aggressive behavior

目的:研究有暴力行为的男性精神分裂症患者的执行功能。方法:对75例有暴力行为史的男性精神分裂症患者(暴力组)和43例无暴力行为史的男性精神分裂症患者(对照组)收集一般资料,评定阳性和阴性症状量表(PANSS),采用言语流畅性测验、连线测验(TMT)、威斯康星卡片分类测验(WCST)和Stroop色词测验评定受试者的执行功能。结果:暴力组的Stroop卡五2min内正确数成绩比对照组显著为差(t=-2.58,P=0.01),暴力组的WCST分类数成绩比对照组显著为差(t=-2.27,P=0.02)。其余认知指标(SIE正确数、SIE时间、卡四2min内正确数、卡四完成时间、卡五完成时间、WCST正确数、WCST错误数、WCST持续错误数、TMT-A时间、TMT-B时间、言语流畅正确数)两组间差异无统计学意义(P均≥0.05)。结论:有暴力行为史的男性精神分裂症患者执行功能较没有暴力行为史的损害明显。

Objective：To examine executive function of male schizophrenic patients with aggressive behavior.Method：Seventy-five male schizophrenic patients and assessed with aggressive behavior and forty-three male schizophrenic patients with non-aggressive behavior were recruited,and assessed with assessement of positive and negative syndrom scale（PANSS）,verbal fluency,trail making test（TMT）,Wisconsin card sorting test（WCST） and Stroop color-word test.Results：Patients with aggressive behavior showed worse than patients with non-aggressive behavior in correction-time within 2 minutes of 5th card of Stroop（t=-2.58,P=0.01）,as well as in categories of WCST（t=-2.27;P=0.02）.There were no significant differences in the other indices（all P≥0.05）.Conclusion：Patients with aggressive behavior were impaired in executive function in male patients with schizophrenia.