摘要
多种干细胞对衰老和病变引起的组织损伤有修复作用,但机制不明。除了可溶性分子,细胞释放的膜微粒(microparticles,MPs)是细胞间信息传递的新机制。MPs是包括干细胞在内的多种细胞在诱导或凋亡后分泌的小囊泡。MPs与靶细胞通过特异的受体-配体相互作用,转移蛋白质、脂质、RNA等生物活性物质。干细胞来源MPs的组成及功能是近年研究的新视点。本文综述MPs的组成、产生机制、在信息传递中的作用以及干细胞衍生MPs的研究进展,为干细胞组织修复机制研究提供新的思路。
Though stem cell transplantation has been confirmed to be useful in repairing aging and diseased tissues,the underlying mechanism remains elusive.In addition to soluble molecules,cells-derived membrane microparticles（MPs） are considered as new mediators served in cross-talk communication among cells.MPs are tiny membrane coated subcellular vesicles released by a variety of cell types including stem cells.MPs may interact with target cells through specific receptor-ligand interactions and transfering proteins,bioactive lipids,mRNA and miRNA.Composition and function of stem cells derived MPs are highlighted in recent years.Here,we give an overview of MPs＇ composition,vesiculation and liberation mechanism,roles involved in communication exchages,and research progress in stem cells derived MPs.The report here might provide some novel information to highlight the stem cells therapy.
出处
《生理科学进展》
CAS
CSCD
北大核心
2012年第2期96-100,共5页
Progress in Physiological Sciences
基金
国家自然科学青年基金(面上项目:81100107)
解放军总医院科技创新基金(面上项目:10KMM22)资助课题
关键词
干细胞
膜微粒
组织修复
信息传递
机制
stem cell
microparticles
tissue repair
information transfer
mechanism
