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生长停滞特异基因6的研究进展 被引量：2

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摘要 生长停滞特异基因6(growth arrest-specific gene 6,Gas6),其表达产物Gas6蛋白作为受体酪氨酸激酶家族(RTKs)中TAM受体(包括Tyro3、Axl、Mer)的配体,与TAM受体相互作用后能发挥抗凋亡、细胞增殖、促吞噬、抑制炎症等效应。Gas6在机体多个系统中具有不同的生物效应,对调节机体功能和维持内环境稳态起着重要作用。同时,Gas6/TAM系统也在一些疾病的发生和发展过程中扮演着关键的角色,提示针对Gas6/TAM系统干预对疾病的治疗具有潜在的应用价值。本文综述了Gas6细胞效应及其相关功能研究的新近认识,并简要介绍了针对Gas6/TAM干预的治疗学意义。
作者 郑嘉奕 卢中秋 姚咏明
机构地区 温州医学院附属第一医院急诊中心 解放军总医院第一附属医院全军烧伤研究所
出处 《生理科学进展》 CAS CSCD 北大核心 2012年第2期119-124,共6页 Progress in Physiological Sciences
基金 国家重点基础研究发展计划项目(2012CB518102) 国家自然科学基金(81071593 81071545 81130035)资助课题
关键词 生长停滞特异基因6 TAM受体 细胞效应 疾病
分类号 R631 [医药卫生—外科学] Q26 [生物学—细胞生物学]
  • 相关文献

参考文献15

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同被引文献13

  • 1George N. Goulielmos,George Samonis,Marina Apergi,Maria Christofaki,Antonis Valachis,Maria I. Zervou,Diamantis P. Kofteridis.C1q but not mannose-binding lectin (Mbl-2 ) gene polymorphisms are associated with type 2 diabetes in the genetically homogeneous population of the island of Crete in Greece[J]. Human Immunology . 2013 (7)
  • 2L. A. Trouw,N. Daha,F. A. S. Kurreeman,S. B?hringer,G. N. Goulielmos,H. J. Westra,A. Zhernakova,L. Franke,E. A. Stahl,E. W. N. Levarht,G. Stoeken‐Rijsbergen,W. Verduijn,A. Roos,Y. Li,J. J. Houwing‐Duistermaat,T. W. J. Huizinga,R. E. M. Toes.Genetic variants in the region of the C 1 q genes are associated with rheumatoid arthritis[J]. Clin Exp Immunol . 2013 (1)
  • 3Chien-Hsing Lee,Nain-Feng Chu,Yi-Shing Shieh,Yi-Jen Hung.The growth arrest-specific 6 (Gas6) gene polymorphism c.834+7G>A is associated with type 2 diabetes[J]. Diabetes Research and Clinical Practice . 2011 (2)
  • 4Hung YJ, Lee CH, Chu NF, et specific 6 levels are associated al. Plasma protein growth arrest- with altered glucose tolerance, inflammation, and endothelial dysfunction [ J ]. Diabetes Care, 2010, 33(8) :1840-1844.
  • 5Sarangi R, Padhi S, Mohapatra S, eta|. Serum high sensitivity C- reactive protein, nitric oxide metabolites, plasma fibrinogen, and lipid parameters in Indian type 2 diabetic males [ J ]. Diabetes Metab Syndr,2012,6( 1 ) :9-14.
  • 6Borgel D, Durand E, Clauser S, et al. Plasma Gas6 levels and coronary artery disease [ J ]. Thromb Haemost, 2009, 101 ( 1 ) : 215-216.
  • 7Guerin E, Sheridan C, Assheton D, et al. SDFl-alpha is associated with VEGFR-2 in human choroidal neovascularisation[ J]. Microvasc Res,2008, 75(3) : 302-307.
  • 8翁建平.对糖尿病流行病学、循证医学及基础研究的探索[J].中山大学学报（医学科学版）,2010,31(2):166-171. 被引量：147
  • 9张岩,杨琴,连丽峰,于本章.补体C1q的功能及其与系统性红斑狼疮的相关性[J].检验医学与临床,2011,8(2):211-212. 被引量：12
  • 10杨旸,祁勇军,梁凤鸣.糖尿病视网膜病变的激光治疗疗效及影响因素的研究[J].海南医学,2011,22(12):42-44. 被引量：12

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生理科学进展
2012年 第2期

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