高密度脂蛋白胆固醇与特发性肺栓塞的关系

Relationship between high-density lipoprotein cholesterol and idiopathic pulmonary embolism

目的探讨高密度脂蛋白胆固醇（HDL—C）与特发性肺栓塞之间的关系。方法收集我院2005年1月至2011年3月确诊的34例特发性肺栓塞患者（PE组）临床资料，选择同时期性别、年龄、基础疾病相匹配的我院体检中心健康体检者109名为对照组。PE组和对照组均空腹10h后次日7：00抽取肘部静脉血，检测血总胆固醇（TC）、HDL—C、低密度脂蛋白胆固醇（LDL—C）。结果PE组与对照组在HDL—C比较中差异有统计学意义[分别为：（1．10±0．28）、（1．49±0．35）mmol／L，t=-5．427、P〈0．05]，而两组在TC、LDL—C差异均无统计学意义（P均〉0．05）。特发性肺栓塞与HDL—C存在一定联系（r=0．284，P〈0．05）。结论TC与LDL—C与特发性肺栓塞可能无关，而HDL-C与特发性肺栓塞存在一定关系。

Objective To investigate the relationship between high-density lipoprotein cholesterol （HDL-C） and idiopathic pulmonary embolism. Methods Clinical data of 34 patients with idiopathic pulmonary embolism from January 2005 to March 2011 were enrolled and healthy people with gender, age and basic diseasematched at the same period were selected as control. The venous blood samples of all the subjects were taken at 7：00 am after 10 hours of fasting and analyzed for total cholesterol （TC）, lower-density lipoprotein cholesterol （LDL-C） and high-density lipoprotein cholesterol （ HDL-C ）. Results Compared with healthy people, patients had reduced HDL-C level with a statistical significance （ （ 1.10 ＋ 0. 28 ） mmol/L vs （ 1.49 ~ 0. 35 ） mmol/L, t = - 5.427, P 〈 0. 05 ）. However, no statistically significant differences were found in the levels of TC and LDL- C（ P 〉 0. 05 ）. HDL-C was correlated with idiopathic pulmonary embolism（ r = 0. 284, P 〈 0. 05 ）. Conclusion The levels of HDL-C, but not TC or LDL-C, might be associated with the idiopathic pulmonary embolism.