体检人群胃蛋白酶原水平分析及异常结果处理对策

Analysis of Abnormal Values of Pepsinogen Level in Healthy People Check-up

目的分析健康体检人群的血清胃蛋白酶原(PG)水平及其影响因素,并对PG异常者的处理对策进行初步探讨。方法选择太湖干部疗养院健康体检人员531名为对象,用时间分辨荧光免疫分析法(TRFIA)检测血清PG值,使用13C尿素呼气试验(13C-UBT)检测该人群的幽门螺杆菌(HP)感染率,并调查分析影响PG水平的相关因素及该人群血清PG异常的检出情况。结果男性血清PGⅠ水平显著高于女性,而PGⅠ<60μg/L与PGⅠ/PGⅡ<6检出率女性显著高于男性;在20～70岁年龄段,随着年龄增长,PGⅠ、PGⅡ水平上升而PGⅠ/PGⅡ比值则下降;HP阳性组的血清PGⅠ、PGⅡ水平显著高于HP阴性组,而PGⅠ/PGⅡ比值则显著低于HP阴性组。结论健康体检人群中,血清PG水平与年龄、性别、HP感染相关,联合测定血清PGⅠ、PGⅡ,计算PGⅠ/PGⅡ比值在健康人群胃病的普查和筛查中具有重要意义。血清PG水平异常较为常见,对该群体的PG异常状况应予重视,应积极对体检人群PG异常者进行分层健康管理。

Objective To analyze the related effect factors on the serum pepsinogen（PG） levels in healthy people check-up,and to explore the management measure for the people with abnormal PG.Method 531 people who took physical examination were involved in this study.The serum PG levels were detected by time resolved f1uoroimmunoassay.The rate of HP infection was detected by 13C urea breath test.Results The serum PGⅠ level in males was significantly higher than that of females,while the detected rate of women with PGⅠ60μg/L and the PG/PGⅡ 6 was significantly higher than that of men.In the age of 20~70 group,the serum PG I and PGⅡ levels were increase gradually as the age increase,while the PGⅠ/ PGⅡ was decreased.The serum PGⅠand PGⅡ levels in HP positive group were significantly higher than that of HP negative group,while the PG/PGⅡ levels were significantly lower than that of HP-negative group.Conclusion The serum PG levels were related with age,gender and HP infection.It is of great importance and significance to combine the determination of serum PGⅠ,PGⅡ and PGⅠ/ PGⅡ ratio for scanning stomach disease in healthy people.