雄激素过多在多囊卵巢综合征发生发展中的作用

The Impact of Androgen Excess on the Initiation and Development of Polycystic Ovary Syndrome

目前多囊卵巢综合征(PCOS)的病因仍不十分明确,尚未发现其确切致病基因,不少研究表明雄激素过多与PCOS的发生密切相关,可能是促进其发生发展的重要因素。现普遍认为高雄激素血症是PCOS发病的根本原因之一,表现为特异性症状和并发症。然而,卵巢多小卵泡、不排卵和胰岛素抵抗的生育期妇女雄激素水平较高,使症状与并发症恶化,这就导致高雄激素血症的恶性循环。就高雄激素血症导致PCOS进行综述。

Although the aetiology of polycystic ovary syndrome （PCOS） is unknown and the search for causative genes is elusive ,androgen excess is generally thought of an important triggers of PCOS.We known that excess androgens is the root cause of PCOS starting from the female fetus,producing the characteristic signs and symptoms which are then exac- erbated by the excess ovarian androgen production from multiple small follicle ,anovulation and insulin resistance in the reproductive life-span, thus setting up a vicious perpetual circle of excess androgen.The paper is biased in support of the hypothesis that androgen excess is the＂root of all evil＂in PCOS.