多囊卵巢综合征遗传易感性的研究进展

Advances in the Hereditary Susceptibility of Polycystic Ovary Syndrome

多囊卵巢综合征(PCOS)是一种生殖功能障碍与糖代谢异常并存的内分泌紊乱性疾病,是导致女性不孕最常见的原因之一,其病因至今尚未明确。目前认为,PCOS复杂的临床表现和生化特征是诸多基因和环境因素共同作用的结果,其生化特征提示其发病与参与甾体激素合成与作用的基因、参与胰岛素分泌和作用的基因、参与促性腺激素作用及调节的基因及炎症因子基因相关。因此,对PCOS的遗传易感性研究将有助于进一步揭示其发病机制。

Polycystic ovary syndrome （PCOS）is one of the endocrine disorders with reproductive dysfunction and glucose metabolism disorders, which is one of the most common reason of infertility of women in the reproductive age. So far, its pathogenesis has not been clear. It is now thought that the complicated clinical manifestations and biochemical characteristics of PCOS are the concomitant result of many genes and environmental factor. Its biochemical characteristics suggests that the pathogenesis is related to abnormal interaction of several genes, including genes involving the synthesize and action of steroid hormone, genes involving the secretion, and action of insulin,genes involving the effect and regulation of gonad stimulating hormone, and inflammatory factor genes.So the study on hereditary susceptibility of PCOS is helpful to further revealing its pathogenesis.