脂联素与多囊卵巢综合征的研究进展

Progress on Adiponectin and Polycystic Ovarian Syndrome

多囊卵巢综合征(PCOS)是一种复杂、多系统的内分泌代谢疾病,病因多元,受多基因遗传和环境因素等共同影响。PCOS女性的肥胖比例明显高于普通女性,故PCOS患者常易出现明显的脂肪功能紊乱和代谢综合征。近年对脂肪组织分泌的重要细胞因子脂联素及脂联素受体的研究发现,脂联素与PCOS中的胰岛素抵抗、远期心血管疾病的发生密切相关;高分子质量脂联素较总脂联素或许更能反映PCOS血清脂联素水平与胰岛素抵抗的关系;脂联素编码基因的多态性使脂联素基因在PCOS中存在易感性。因此,脂联素已成为PCOS的研究热点。

Polycysfic ovary syndrome （PCOS）is a complicated, multi-system endocrine and metabolic disease. Its etiology is impaired by multiple genetics and environmental factors. Obesity is significantly higher in PCOS than average women. As a resuh,PCOS patients have obvious adipose tissue dysfunction and metabolic syndrome. With the recent in-depth study on adipocytokines secreted from adipose tissue,it was discovered that adiponectin and its receptors were closely related to insulin resistance and long-term cardiovascular disease in PCOS. High molecular weight adiponectin may be better to reflect the actual role of insulin resistance in PCOS. Polymorphism of adiponectin gene may be the susceptibility gene in PCOS. Thus, adiponectin has become the focus of PCOS research.