血清TGAb、TPOAb在甲状腺疾病中的应用价值

The Value of Serum TGAb and TPOAb Detection in Thyroid Diseases

目的探讨甲状腺球蛋白抗体(TGAb)和甲状腺过氧化物酶抗体(TPOAb)水平在甲状腺功能亢进(甲亢)和原发性甲状腺功能减退症(甲减)中的改变及其临床意义。方法将100例甲亢患者分成4组:甲亢初诊组、甲亢复发组、甲亢缓解组和治疗后转向甲减组。采用免疫化学发光法分别检测100例甲亢、60例原发性甲减患者和30例正常人的血清TGAb和TPOAb。结果甲亢组和原发性甲减组的TGAb和TPOAb阳性率与正常组比较差异均有统计学意义(P<0.01);100例甲亢患者治疗前后TPOAb阳性率明显高于TGAb的阳性率;无论是初诊组、复发组还是缓解组治疗前后两种抗体检测的阳性率比较,差异均有统计学意义(P<0.05)。结论 TGAb和TPOAb的定量检测在甲状腺疾病的鉴别、诊断及治疗中具有参考价值,TPOAb具有相对较高的临床价值。

Objective To investigate the changes of thyroglobulin antibody（TGAb） and thyroid peroxidase antibody（TPOAb） in patients with hyperthyroidism and hypothyroidism,and evaluate its clinical value.Methods 100 cases with hyperthyroidism were divided into four groups： newly diagnosed hyperthyroidism group,hyperthyroidism relapse group,remission of hyperthyroidism and hypothyroidism after treatment groups.Serum levels of TGAb and TPOAb were detected in 100 hyperthyroidism,60 hypothyroidism cases and 30 healthy adults.Results The positive rates of TGAb and TPOAb in patients with hyperthyroidism and hypothyroidism were higher than those of normal control group.The TPOAb-positive rates in pre-therapy and post-treatment were significantly higher than that of TGAb in 100 patients with hyperthyroidism patients in pretherapy and post-treatment.No matter newly diagnosed hyperthyroidism group,hyperthyroidism relapse group,remission of hyperthyroidism group,hyperthyroidism after treatment group,the two antibody positive rates were different significantly between pretherapy and post-treatment.Conclusion Quantitative detection of TGAb and TPOAb are significant in identification,diagnosis and treatment of thyroid disease.Clinical value of TPOAb is higher relatively than TGAb.