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原发性胆汁性肝硬化动物模型研究进展 被引量:5

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摘要 近年来原发性胆汁性肝硬化发病率逐年上升,但该病的发病机制尚不明确,寻找合适的动物模型揭示该病的发病机制及其防治至关重要,该文对国内外相关动物模型进行分析,描述各类动物模型的优势与不足,目的在于完善原发性胆汁性肝硬化的相关模型,为今后原发性胆汁性肝硬化的发病机制及药物治疗研究提供实验平台。
作者 马欢 王邦茂
出处 《国际消化病杂志》 CAS 2012年第2期93-95,共3页 International Journal of Digestive Diseases
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参考文献25

  • 1Allina J, Hu B, Sullivan DM, et al. T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary hiliary cirrhosis. J Autoimmun, 2006, 27: 232-241.
  • 2He XS, Ansari AA, Ridgway WM, et al. New insights to the immunopathology and autoimmune responses in primary biliary cirrhosis. Cell Immunol, 2006, 239: 1-13.
  • 3Van de Water J, Gershwin ME, Leung P, et al. The autoepitope of the 74 kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. J Exp Med, 1988, 167: 1791 -1799.
  • 4Shimoda S, Van de Water J, Ansari A, et al. Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis. J Clin Invest, 1998, 102: 1831-1840.
  • 5Leon MP, Bassendine MF, Wilson JL, et al. Immunogenicity biliary epithelium: investigation of antigen presentation to CD4 + T cells. Hepatology, 1996, 24:561- 567.
  • 6Aoki CA, Roifman CM, Lian ZX, et al. IL -2 receptor alpha deficiency and features of primary biliary cirrhosis. J Autoimmun, 2006, 27: 50-53.
  • 7Zeniya M. Lessons from animal models of primary biliary cirrhosis. J Gastroenrol Hepatol, 2000, 15:342- 343.
  • 8Okada C, Akbar SM, Horiike N, et al. Early development of primary biliary cirrhosis in female C57BL/6 mice because of poly I:C administration. Liver Int, 2005, 25:595- 603.
  • 9Lyons PA, Hancock WW, Denny P, et al. The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137. Immunity, 2000, 13:107-115.
  • 10Irie J, Wu Y, Wicker LS, et al. NOD. c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogeneticaliy models human primary biliary cirrhosis. J Exp Med, 2006, 203:1209-1219.

同被引文献31

  • 1许良中,杨文涛.免疫组织化学反应结果的判断标准[J].中国癌症杂志,1996,6(4):229-231. 被引量:1365
  • 2周一平.用Excel软件进行药物毒理实验的随机分组[J].药学进展,2005,29(9):425-427. 被引量:43
  • 3John Almeida,Sumedha Galhenage,Jennifer Yu,Jelica Kurtovic,Stephen M Riordan.Gut flora and bacterial translocation in chronic liver disease[J].World Journal of Gastroenterology,2006,12(10):1493-1502. 被引量:38
  • 4Domenicali M, Caracen P, Giannone F, et al. A novel model ofCC14 induced cirrhosis with ascites in the mouse [ J I. Joum of Hepatology,2009, (51) :991 -999.
  • 5TALWALKAR JA,SOUTO E,JORGENSEN RA,et al.Natural history of pruritus in primary biliary cirrhosis[J].Clin Gastroenterol Hepatol,2003,1(4):297-302.
  • 6KUIPER EM,HANSEN BE,DE VRIES RA,et al.Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid[J].Gastroenterology,2009,136(4):1281-1287.
  • 7Working Subgroup(English version)for Clinical Practice Guidelines for Primary Biliary Cirrhosis.Guidelines for the management of primary biliary cirrhosis:the intractable hepatobiliary disease study group supported by the Ministry of Health,Labour and Welfare of Japan[J].Hepatol Res,2014,44(Suppl S1):71-90.
  • 8KOHJIMA M,ENJOJI M,YADA R,et al.Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism[J].Liver Int,2015,35(3):1095-1102.
  • 9INVERNIZZI P,SELMI C,GERSHWIN ME.Update on primary biliary cirrhosis[J].Dig Liver Dis,2010,42(6):401-408.
  • 10BERNUZZI F,FENOGLI D,BATTAGLIA F,et al.Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis[J].Autoimmune,2010,35(3):176-180.

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