丙种球蛋白不同疗法治疗新生儿ABO溶血病疗效分析

The Efficacy Analysis of Different Gamma Globulin Therapy for ABO Hemolytic Disease Newborns

目的:观察探讨丙种球蛋白治疗新生儿ABO溶血病的临床使用方法及其临床效果。方法:选取我院自2006年3月至2010年10月收治的98例ABO溶血病新生儿,均给予丙种球蛋白治疗,按照丙种球蛋白的使用剂量分为A组(大剂量组)和B组(小剂量组),各49例,观察比较两组患儿的临床治疗效果。结果:①两组患儿治疗后总胆红素、RBC、Hb、HCT指标比较均无明显差异(P>0.05),无统计学意义。②两组患儿皮肤黄疸消退及蓝光照射治疗的时间比较均有显著差异(P<0.01),具有统计学意义。结论:应用大剂量的丙种球蛋白治疗新生儿ABO溶血病效果理想,可缩短黄疸消退及蓝光照射的时间,值得推广。

Objective： To observe and discuss the clinical use and clinical results of gamma globulin in treatment of ABO hemolytic disease.Method： At first,we choose 98 cases of ABO hemolytic disease newborns in our hospital from Mar.2006 to Oct.2010.The newborns were given gamma globulin treatment.According to the use of gamma globulin,The dosage was divided into group A（high-dose group） and group B（low-dose group） and each group with 49 cases.Then,we observed and compared the different clinical efficacy of two groups.Result：①There＇s no significant differences in total bilirubin,RBC,Hb,HCT indicators between the two groups.②There＇s great difference in jaundice and blue skin irradiation time between the two groups（P0.01） with statistical significance.Conclusion： The results of application of large doses of gamma globulin in treating neonatal ABO hemolytic disease are satisfactory,which can not only shorten time for blue-ray irradiation,but also it is worth promoting.