胃食管反流病相关因素研究

Study the Related Factors of Gastroesophageal Reflux Disease

目的:分析胃食管反流病的相关危险因素。方法:选择我科诊治的胃食管反流病患者29例为观察组,另选择31例健康志愿者为对照组,对两组研究对象的饮食和生活习惯进行问卷调查,测量其食管及胃内压并进行24h食管PH值监测。结果:观察组中常进食过饱、睡前进食,喜油腻食物、辛辣食物及饮酒、吸烟、喝咖啡的比例均明显高于对照组(P<0.05)。观察组患者LESL均值为(3.28±0.31)cm,GP均值为(1.62±1.03)kPa,LESP/GP为0.54±0.43,与对照组相比均有统计学差异(P<0.05)。观察组胃酸反流时间为(201.34±198.23)min,PH值<4时间比例平均为(22.13±17.53)%,胃酸清除时间(1.49±1.31)min/次,均明显长于或高于对照组(P<0.05)。结论:不良的饮食习惯、食管下括约肌功能异常及食管廓清能力的降低等都是胃食管反流病的重要危险因素,在临床工作中应该采取积极的干预措施。

Objective： To analyze the related factors of gastroesophageal reflux disease.Method： 29 patients with GERD were chosen as the observation group,31 healthy volunteers were selected for the control group.Subjects of diet and lifestyle questionnaires were performed,the pressure of the esophagus and stomach and 24h esophageal pH value were measured.Result： The rate of often eating too full,eating before going to bed,Prefering greasy food,spicy food and alcohol consumption,smoking,coffee drinking in the observation group were significantly higher than the control（P 0.05）.The patients mean LESL was（3.28 ± 0.31） cm,mean GP was（1.62 ± 1.03） kPa,LESP / GP was 0.54 ± 0.43,there were significant difference compared with the control group（P 0.05）.In the observation group,the acid reflux time was（201.34 ± 198.23） min,the average ratio pH value less than 4 was（22.13 ± 17.53）%,acid clearance time was（1.49 ± 1.31） minutes once,they were longer or higher than the control group obviously（P 0.05）.Conclusion： Poor eating habits,the lower esophageal sphincter dysfunction and reduced capacity of esophageal clearance are all important risk factors for GERD in clinical work,We should take active measures to intervent.