病毒性肝炎患者两类免疫效应细胞的功能变化

Research of T lymphocyte subtypes and the phagocytosis activity of macrophages in the patients with virul hepatitis

为探讨病毒性肝炎患者体内细胞免疫功能的变化规律及相互关系。采用APAAP法、斑蝥皮泡法检测T细胞亚群、巨噬细胞吞噬率 (PR)及吞噬指数 (PI) ,并分析其相互关系。结果显示病毒性肝炎组CD3+ 细胞、CD4+ 细胞、CD4+ /CD8+ 比值降低、CD8+ 细胞升高 ,与对照组比较有显著差异 (P <0 0 1) ,各型病毒性肝炎组病人PR与CD4+ /CD8+ 比值正相关 ,其中CAH组相关系数r =0 76 4(P <0 0 5 )。病毒性肝炎患者T细胞及巨噬细胞免疫功能均降低 ,且密切相关。结果有助于了解病毒性肝炎患者免疫功能的整体变化 ,对病毒性肝炎的免疫学诊断及免疫功能调整有一定意义。

WT5”BZ] To Detect T lymphocyte, macrophages immune function in the patients with virul hepatitis. T lymphocyte subtypes including CD3 +、CD4 +、CD8 + and phagocytosis rate (PR) and index (PI) of macrophages were measured in virul hepatitis. The results showned that the values of CD3 +、CD4 +、CD4 +/CD8 + were lower and CD8 + were higher in the virul hepatitis patients than in nomal control (P<0 01);The values of PR and PI were lower in patients than in controls (P<0 01);The values of PR and CD4 +/CD8 + were closely related in patients. T lymphocyte immune function, the phagocytosis activity of macrophages in virul hepatitis patients were significantly decreased, the changes of determent values of the two systems were closely interrelated. [WT5”HZ]