未分化结缔组织病合并骨髓增生异常综合征1例

A case report of undifferentiated connective tissue disease associated myelodysplastic syndrome

骨髓增生异常综合征（myelodysplastic syndrome,MDS）伴发风湿性疾病的病例较为少见,二者在发病机制上可能有相关性,近年来成为学者们研究的热点。山西医科大学第二医院风湿免疫科于2011年12月收治1例未分化结缔组织病（undiffe-rentiated connective tissue diseases,UCTD）合并MDS患者,现报告如下。

A 58-year-old man exhibited polyarthritis,fever,thrombocytopenia and progressive anemia.Undifferentiated connective tissue diseases(UCTD) was diagnosed based on laboratory and radiographic findings.After diagnosis,the patient received glucocorticoid and blood-transfusion.The symptoms were improved notablely.However,the level of hemoglobin was lower than normal(between 57 g/L and 75 g/L).Thrombocytes were 19 000/microl to 32 000/microl.Bone marrow aspiration revealed highly abnormal cell morphology,indicating myelodysplastic syndrome(MDS).A diagnosis of UCTD with MDS was made.The patient was successfully treated by decitabine and thalidomide(an immunosuppressive regimen).It is necessary to promptly examine bone marrow cell morphology and chromosomal aberration in cases with connective tissue diseases complicated by sudden cytopenia and thrombocytopenia. Abstract:SUMMARY A 58-year-old man exhibited polyarthritis,fever,thrombocytopenia and progressive anemia.Undifferentiated connective tissue diseases(UCTD) was diagnosed based on laboratory and radiographic findings.After diagnosis,the patient received glucocorticoid and blood-transfusion.The symptoms were improved notablely.However,the level of hemoglobin was lower than normal(between 57 g / L and 75 g / L).Thrombocytes were 19 000 / microl to 32 000 / microl.Bone marrow aspiration revealed highly abnormal cell morphology,indicating myelodysplastic syndrome(MDS).A diagnosis of UCTD with MDS was made.The patient was successfully treated by decitabine and thalidomide(an immunosuppressive regimen).It is necessary to promptly examine bone marrow cell morphology and chromosomal aberration in cases with connective tissue diseases complicated by sudden cytopenia and thrombocytopenia.