急性链球菌感染后肾炎患儿血、尿白介素-8的变化和意义

The detection of serum and urinary interleukin - 8 and its clinical significance in childhood acute poststreptococcal glomerulonephritis

为探讨急性链球菌感染后肾炎(APSGN)患儿血、尿白介素-8(IL-8)的变化和意义。用ELISA方法检测34例APSGN患儿急性期和恢复期及16例对照组儿童血、尿IL-8浓度。急性期患儿肾功能降低11例,肾功能正常23例。结果:APSGN患儿急性期尿IL-8水平(55.84pg/mg肌酐)较恢复期(32.55pg/mg肌酐)和对照组(11.21pg/mg肌酐)显著升高(P<0.05)。急性期肾功能降低患儿尿IL-8水平(89.97pg/mg肌酐)较肾功能正常患儿(41.00pg/mg肌酐)显著升高(P<0.05)。尿IL-8浓度与尿蛋白浓度呈显著正相关(r=0.716,P<0.01)。提示APSGN患儿尿IL-8水平与临床病情相关。

To explore the change of serum and urinary interleukin - 8 and its clinical significance in childhood acute poststreptococcal glomerulonephritis (APSGN), the levels of serum and urinary interleukin -8 were detected by ELISA in 16 normal control children and in 34 APSGN cases during both of acute phase and convalescent phase,respectively. Urinary protein and creatinine level were also measured. The decrased renal function was found in 11 cases of 34 APSGN patients. The results showed that urinary IL -8 level in the APSGN patients in acute phase (55. 84pg/mg creatinine) was significantly higher than that in convalescent phase (32. 55pg/mg creatinine) and that in the control group (11.21pg/mg creatinine) (P< 0.05). Urinary IL - 8 level in APSGN case with decreased renal function was also elevated obviously (89. 97pg/mg creatinine) than that with normal renal function (41. 0 pg/mg creatinine) (P<0. 05). There was a significant correlation between urinary IL -8 level and urinary protein concentration (r=0. 716,P<0. 01). It is concluded that urinary IL -8 level was markedly eorrela-ted with clinical situation in APSGN patients.