舒芬太尼与氟比洛芬酯复合曲马多对雷米芬太尼复合麻醉苏醒期的影响比较

Effect of sufentanil or flurbiprofen axetil combined with tramadol hydrochloride on patients in recovery period after remifentanil-based general anesthesia

目的:比较超前使用舒芬太尼与氟比洛芬酯联合曲马多对雷米芬太尼复合全麻苏醒期的影响。方法:将40例择期腹腔镜胆囊切除术患者随机分为舒芬太尼组(A组)和氟比洛芬酯复合曲马多组(B组),每组20例。A组手术结束前5 min,静脉注射舒芬太尼0.15μg/kg;B组手术开始前10 min,静脉注射氟比洛芬酯50 mg,手术结束前10 min,静脉注射氟比洛芬酯50 mg和曲马多2 mg/kg。记录并比较2组苏醒时间、苏醒后的镇痛评分(VRS)和不良事件发生例数。结果:A组苏醒时间长于B组(P<0.01);B组苏醒拔管后10、20、30 min的VRS均明显高于A组(P<0.01);2组拔管后2 h期间不良事件发生率差异无统计学意义(P>0.05)。结论:舒芬太尼在雷米芬太尼复合麻醉苏醒早期的镇痛效果较氟比洛芬酯复合曲马多更佳。

Objective：To explore the effect of sufentail or flurbiprofen axetil combined with tramadol hydrochloride on patients in the recovery period after remifentanil-based general anesthesia.Methods：Forty patients undergoing laparoscopic cholecystectomy were evenly divided into two groups：sufentanil group（group A） and flurbiprofen axetil combined with tramadol hydrochloride group（group B）.Group A received intravenous injection of 0.15 μg/kg sufentanil five minutes before the end of the operation,and group B received intravenous injection of 50 mg flurbiprofen axetil ten minutes before the operation and 50 mg flurbiprofen axetil with 2 mg/kg tramadol hydrochloride ten minutes before the end of the operation.The recovery time,verbal rating scale and incidence of side effects were evaluated.Results：The recovery time of group A was longer than that of group B（P〈0.01）.The VRS of group B at 10,20 and 30 min after extubation was significantly higher than that of group A（P〈0.01）.The incidence of side effects was similar 2 h after extubation between the two groups（P〉0.05）.Conclusions：Sufentanil provides more effective analgesia than flurbiprofen axetil combined with tramadol hydrochloride for patients in the early recovery period after remifentanil-based general anesthesia.