摘要
目的探讨医用几丁糖对兔眼增生性玻璃体视网膜病变的防治作用。方法36只实验兔随机分为3组：空白组，模型组和实验组。除空白组外其余2组制备增生性玻璃体视网膜病变动物模型，分别将生理盐水（0．1ml）和浓度为2％的医用几丁糖（0．1ml）注射入模型组和实验组玻璃体腔内，空白组不进行注射。采用酶联免疫吸附试验检测玻璃体腔中碱性成纤维细胞生长因子的含量。结果实验组增生性玻璃体视网膜病变的严重程度明显低于模型组（P〈0．01），玻璃体腔内碱性成纤维细胞生长因子的含量较模型组明显降低（q=6．05，P〈0．01）。结论医用几丁糖可以降低玻璃体腔内碱性成纤维细胞生长因子的含量，抑制增生性玻璃体视网膜病变的发展。
Objective To study the preventing effect of medicinal Chitosan on proliferative vitreoretinopathy （PVR）. Method Thirty six rabbits were selected randomly and divided into three groups： blank group （nothing）, model group（ received an intravitreal injection of 0. 1 ml saline） and experiment group（received an intravitreal injection of 0. 1 ml chitosan）, and they were induced to PVR model except blank group. PVR model of rabbit was made by injecting blood. The content of bFGF was measured by Enzylmelinked immunosorbent assy. Results Hyperplasia level of vitreous and retina in experiment group was lower than model group. The contents of bFGF in experiment group were lower than model group. Conclusion Chitoasn can decrease the content of bFGF in the vitreous body and then prevent the proliferative vitreoretinopathy.
出处
《中华眼外伤职业眼病杂志》
2012年第4期246-248,共3页
Chinese Journal of Ocular Trauma and Occupational Eye Disease
