膀胱灌注10-HCPT预防肿瘤复发的临床观察

Postoperative intravesical installition of 10-Hydroxyl Camptothecine for superficial bladder tumor: clinical results of prophylactic effects on the reccurrence

目的 :探讨膀胱灌注 10 -羟基喜树碱 (10 - HCPT)预防肿瘤复发的临床疗效。方法 :对 2 6例膀胱肿瘤患者在施行膀胱部分切除术或经尿道膀胱肿瘤电气化术后作 10 - HCPT10 m g加生理盐水 2 0 ml膀胱灌注治疗。结果 :所有患者均获 16～ 5 7个月随访 ,平均 34 .7个月 ,2 4例无肿瘤复发 ;2例于 2年后肿瘤复发。结论 :膀胱肿瘤术后膀胱灌注 10 - HCPT治疗效果可靠 ,副作用微小 ,无全身性化疗反应发生。

Purpose: To investigate the clinical results of prophylactic effects on the reccurrence of bladder tumor with intravesical installition of 10 Hydroxyl Camptothecine. Methods: Postoperative intravesical installition of 10 Hydroxyl Camptothecine for superficial bladder tumor were conducted for 26 cases and the clinical results of prophylactic effects on the reccurrence were observed. Results: The duration of following Up was 16~57 months, on average 34.69 months. There was no tumor relapse in 2 years after operation, however,2 patients had tumor relapse in bladder after 2 years of operation.Conclusions: Postoperative intravesical installition of 10 Hydroxyl Camptothecine for superficial bladder tumor has good prophylactic effects on the reccurrence without heavy side effects.