膀胱移行细胞癌TGFβ_1和TGFβ_3的表达及临床意义

Expression of transforming growth factor β of transitional cell carcinoma and their clinical significance

目的 :研究膀胱移行细胞癌 (膀胱癌 )组织中转化生长因子β1 (TGFβ1 )与转化生长因子β3(TGFβ3)的表达及其与肿瘤生物学行为的关系。方法 :采用免疫组织化学技术 ABC法对 38例首发膀胱癌中 TGFβ1 与 TGFβ3的表达进行检测。结果 :高分化、浅表性、随访无复发的膀胱癌中 TGFβ1 与 TGFβ3在胞浆中的表达显著高于低分化、浸润性、随访复发的膀胱癌。结论 :胞浆内 TGFβ1 与 TGFβ3可能在早期膀胱癌中起负性调节作用 ;TGFβ1与 TGFβ3在胞浆中表达的降低或缺失可能导致膀胱癌恶性增殖与发展 ;TGFβ1 与 TGFβ3在胞浆中的表达水平可作为膀胱癌诊疗及判断预后的有用指标。

Purpose: To investigate the expression of transforming growth factor β 1 (TGFβ 1) and transforming growth factor β 3 (TGFβ 3) and their relationship to the biological behavior of bladder transitional cell carcinoma(bladder TCC). Methods:38 samples of primary bladder TCC were determined for their expression of TGFβ 1 and TGFβ 3 by ABC immunohistochemical staining. Results: The expression of TGFβ 1 and TGFβ 3 in patients with poor differentiated, invaded or recurring bladder TCC was lower than that in patients of well differentiated ,superficial or nonrecurring bladder TCC . Conclusions: TGFβ 1 and TGFβ 3 may be negative regulators for growth of bladder TCC. Decreased or deficient cytoplasm expression of transforming growth factor β may cause malignant proliferation and progression of bladder TCC.