宫颈癌组织中NF-κBp65的表达及其意义

The Expression and Significance of Nuclear Transcription factor κB p65 in Cervical Cancer

目的探讨癌基因核转录因子-κB(NF-κB)p65在宫颈癌中的表达及临床意义。方法应用免疫组化方法检测65例宫颈癌组织、110例上皮内瘤样病变(CIN)组织及28例宫颈炎症组织中NF-κBp65的表达情况。结果 NF-κBp65在宫颈癌组中阳性表达率与宫颈炎症组、宫颈CINⅠ～Ⅱ期及Ⅲ期组的阳性表达率差异有统计学意义。宫颈癌组织中低分化组NF-κBp65阳性率显著高于高、中分化组,有淋巴结转移组NF-κBp65阳性率显著高于无淋巴结转移组。结论 NF-κBp65在宫颈癌中表达上调,提示其可能与宫颈癌发生、发展密切相关。

Objective To Investigate the expression and clinical significance of tumor gene NF-κB p65 in cervical cancer.Methods Immunohistochemical method was used to detect the expression of NF-κB p65 in 65 cases of cervical cancer and 110 cases of CIN and 28 cases of cervical inflammatory tissues.Results There are significant differences of positive expression rate of NF-κB p65 among cervical cancer group and cervical inflammation group and cervical dysplasia group CINⅠ-Ⅱand stage Ⅲ.The positive rate of NF-κB p65 in poorly differentiated group was significantly higher than the highly differentiated group in cervical cancer,positive rate of NF-κB p65 in lymph node metastasis group was significantly higher than those without metastasis group.Conclusion It is suggested that the high expression of NF-κB p65 in cervical cancer are associated with the pathogenesis and development of cervical cancer.