糖尿病足患者病原菌分布及药物敏感性分析

Distribution and drug resistance of pathogens in patients with diabetic foot

目的分析本地区糖尿病足患者感染病原体分布情况及药物敏感性特点,为临床合理选用抗菌药物提供依据。方法回顾性分析2005年1月至2011年3月收治的125例糖尿病足患者的足分泌物细菌真菌培养及药敏资料。结果 143份合格标本中共培养出病原菌112株,其中革兰阴性杆菌59株(52.7%)、革兰阳性球菌41株(36.6%)、真菌12株(10.7%)。革兰阴性杆菌对碳氢酶烯类抗菌药物、莫西沙星、哌拉西林/他唑巴坦敏感性最高;革兰阳性球菌对糖肽类抗菌药物、碳氢酶烯类抗菌药物及莫西沙星敏感性最高。结论糖尿病足患者应及早、多次的行分泌物病原学检查,指导临床筛选敏感抗菌药物,减少耐药菌株产生。

Objective To analyze the distribution and drug resistance of pathogenic bacteria in patients with diabetic foot,in order to provide a basis for reasonable application of antibiotics in our district.Methods A retrospective analysis was made for 125 cases.Results 143 samples were collected in which 112 samples reveal pathogen growth.59 samples were Gram-negative bacteria（52.7%）,41 samples were Gram-positive bacteria（36.6%）,and 12 samples were fungi（10.7%）.The major responsive antibiotics to Gram-negative bacteria were carbapenem drugs,Moxifloxacin,and Piperacillin / tazobactam drugs.The major responsive antibiotics to Gram-positive bacteria were glycopeptides drugs,carbapenem drugs,and Moxifloxacin.Conclusion We should more detect pathogens in patients with diabetic foot early.The results of distribution and drug resistance of pathogens could help the choice of drugs.Rational choice of antimicrobial agents should be directed reduce the resistance rate.