摘要
目的 :观察肺瘤平二号膏对中晚期肺癌患者和荷Lewis肺癌之C57BL/ 6J小鼠血清中TXB2 和 6 酮 PGF1α水平的影响 ,阐述肺瘤平二号膏的部分作用机理。 方法 :临床研究选取 3 0例中晚期肺癌患者服用肺瘤平二号膏 1个月 ,治疗前后用放射免疫方法观察患者血清中TXB2 和 6 酮 PGF1α水平的变化。动物实验选取 5 0只C57BL/ 6J近交系小鼠分为正常对照组 ( 2 0只 ) ,对照组 ( 10只 )、中药组 ( 10只 )和阿司匹林组 ( 10只 )。除正常对照组小鼠外 ,其余各组小鼠在接种Lewis肺癌后给药观察2 1d ,心脏取血观察血清中TXB2 和 6 酮 PGF1α水平的变化 ,并对比各组小鼠瘤重、脾重和胸腺重量的改变。 结果 :肺瘤平二号膏使TXB2 / 6 酮 PGF1α比值明显下降 ,但它们与正常样本相比仍有差别。肺瘤平二号膏对Lewis肺癌有一定的抑制作用 ,并对荷瘤小鼠的胸腺和体重有一定的保护作用。 结论 :肺瘤平二号膏对TXB2 和TXB2 / 6 酮 PGF1α比值的调节作用有助于肺癌宿主对转移的预防和治疗。
Objective:To investigate the regulation to serum TxB 2 and 6-keto-PGF 1α of advanced lung cancer patients and C 57 BL/6J inbred mice implanted Lewis lung carcinoma,and to explain the therapeutic mechanism of the complex pres cription Feiliuping Ⅱ.Methods:In clinical studies,changes of TxB 2 and 6-keto-PGF1α on thirty advanced lung cancer patients having received Feiliuping Ⅱ for one month were evaluated by radioimmunoassay.In animal studies,fifty C 57 BL/6J inbred mice were divided into normal control group(20 mice),control group (10 mice),Feiliuping Ⅱ group(10 mice) and Aspirin group (10 mice).The serum TxB 2 and 6-keto-PGF1α levels,and tumor weight,spleen weight and thymus weight were evaluated after 21 days.Results:Feiliuping Ⅱ reduced the TxB 2/6-keto-PGF1α ratio,but the ratio was still higher than that in the normal control group.Feiliuping Ⅱ inhibited the growth of Lewis lung carcinoma and protected the thymus and the body weight of C 57 BL/6J inbred mice with the tumor.Conclusion:The regulation of TxB 2/6-keto-PGF1α ratio on lung cancer host by Feiliuping Ⅱ may be of help to prevent and treat malignant metastasis.
出处
《中国中西医结合外科杂志》
CAS
2000年第1期6-8,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
国家中医药管理局青年基金!No 93C0 11
