治疗型乙肝疫苗治疗慢性病毒性乙型肝炎的疗效观察

Obversation of therapeutic results aganist chronic hepatitis B of the therapeutic hepatitis B vaccines

目的 评价治疗型乙肝疫苗在慢性乙型肝炎治疗中的应用价值。方法 应用ELISA方法和聚合酶链反应方法检查 6 0例HBsAg、HBeAg、抗HBc阳性且HBVDNA阳性的慢性乙肝患者治疗前后血清中上述指标及临床变化。结果 用治疗型乙肝疫苗Ⅰ、Ⅱ、Ⅲ型治疗后 ,HBeAg、HBVDNA总的阴转率分别是 2 3.33%、16 .6 7% ,抗HBe总的阳转率为 16 .6 7% ;肝组织炎症改变 (G)有不同程度的减轻 ,纤维化程度 (S)无明显改变。结论 治疗型乙肝疫苗对慢性乙型肝炎有一定的疗效 (P <0 .0 5 ) ,但为提高疗效 ,对其剂型、剂量和疗程有待进一步研究。

Objectives The study was carried out to evaluate the practical efficacy of therapeutic Hepaitis B.Methods The clinical variation of the markers of HBV and HBVDNA in serum were respectively detected with ELISA and PCR method in 60 patients with chronic hepatitis B before and after treatment. Results The total negative conversion rates of serum HBeAg and HBVDNA were 23.33%、16.6%,respactively,and the total positive conversion rates of α-HBe was 16.67% after treating with Ⅰ、Ⅱ and Ⅲ type therapeutic hepatitis B vaccines.The degree of inflammation in liver tissue was lightered,and that of hepatic fibrosis had no obvious change.Conclusions The therapentic hepatitis B vaccine had some efficacy aganist chronic hepatitis B.otherwise it is necessary to study it′s dose and duration of treatment further in order to improve it′s therapentic effect