原发性高血压患者血清Salusin-α、UⅡ与颈动脉IMT的相关性分析

Correlation analysis of serum Salusin-α and U Ⅱ levels with IMT in patients with essential hypertension

目的探讨原发性高血压(EH)患者血清Salusin-α和尾加压素Ⅱ(UⅡ)水平与颈动脉内膜中层厚度(IMT)的相关性。方法选取EH患者100例和同期健康体检者100名,分别采用酶联免疫吸附试验(ELISA)和放射免疫法检测血清Salusin-α和UⅡ水平,高分辨超声测定IMT作为大血管动脉粥样硬化(AS)程度的指标,并分析Salusin-α、UⅡ与IMT之间的关系。结果与正常对照组相比,EH组的IMT明显增厚(P<0.01),血清UⅡ水平明显升高,而Salusin-α水平明显降低(P<0.01);粥样斑块组、IMT增厚组与对照组相关性分析,血清Salusin-α水平与IMT呈负相关(r=-0.527,P<0.01),而UⅡ水平与IMT呈正相关(r=0.612,P<0.05)。结论血清Salusin-α和UⅡ水平的变化与EH患者IMT增厚密切相关,提示Salusin-α和UⅡ可能影响高血压患者的动脉弹性并参与了EH患者AS病理过程,可能成为预测EH并发AS严重程度的新临床指标。

Objective To investigate the correlation between serum Salusin-α,urotensinⅡ（U Ⅱ） and carotid intima-media thickness（IMT） in patients with essential hypertension（EH）.Methods A total of 100 patients with EH and 100 healthy controls in the same time were enrolled.Serum Salusin-α and U Ⅱ were detected by enzyme-linked immunosorbent assay（ELISA） and radioimmunoassay respectively.The IMT was detected by high-resolution ultrasound which was as an index of large vessel atherosclerosis（AS）.The correlation of serum Salusin-α and U Ⅱ levels with IMT was analyzed.Results Serum U Ⅱ level and IMT were significantly higher in EH group than those in control group（P0.01）,while Salusin-α level was significantly lower in EH group than those in control group（P0.01）.IMT was negatively correlated with serum Salusin-α（r=-0.527,P0.01）,and positively correlated with serum U Ⅱ（r=0.612,P0.05）.Conclusions The change of serum Salusin-α and U Ⅱ has a correlation with carotid IMT,which suggests that Salusin-α and U Ⅱmay affect the resilience of arteries and participate the pathological process of AS.Serum Salusin-α and U Ⅱ may be new markers correlated with the severity of AS for clinical application.