期刊文献+

内源性强啡肽/κ受体系统在痛与镇痛领域的研究进展 被引量:1

下载PDF
导出
摘要 阿片肽家族广泛参与伤害性感受的调节,内源性阿片类物质[内啡肽(endorphin)、脑啡肽(enkephalin)和强啡肽(dynorphin,Dyn)]在镇痛中起重要作用[1]。长久以来,阿片受体家族中备受疼痛研究者青睐的一直是μ受体,与疼痛相关的机制探讨、
出处 《广东医学》 CAS CSCD 北大核心 2012年第8期1190-1193,共4页 Guangdong Medical Journal
基金 国家自然科学基金面上项目(编号:81071307)
  • 相关文献

参考文献24

  • 1项红兵,田玉科.转阿片肽基因镇痛的研究进展[J].国外医学(麻醉学与复苏分册),2004,25(2):83-86. 被引量:8
  • 2张永福,项红兵.DREAM信号通路调控疼痛敏感化的研究进展[J].实用医学杂志,2009,25(1):151-153. 被引量:1
  • 3MANSOUR A,KHACHATURIAN H,LEWIS M E. Anatomy of CNS opioid receptors[J].Trends in Neurosciences,1988,(07):308-314.
  • 4YEOMANS D C,JONES T,LAURITO C E. Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin[J].Molecular Therapy,2004,(01):24-29.
  • 5CHENG H Y,PITCHER G M,LAVIOLETTE S R. DREAM is a critical transcriptional repressor for pain modulation[J].Cell,2002,(01):31-43.
  • 6ZHANG Y,SU P,LIANG P. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit[J].The Journal of Neuroscience,2010,(22):7575-7586.
  • 7RIVERA ARCONADA I,BENEDET T,ROZA C. DREAM regulates BDNF-dependent spinal sensitization[J].MOLECULAR PAIN,2010.95.doi:10.1186/1744-8069-6-95.
  • 8SIMONIN F,VALVERDE O,SMADJA C. Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain,impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal[J].EMBO Journal,1998,(04):886-897.
  • 9SHIMOYAMA M,TATSUOKA H,OHTORI S. Change of dorsal horn neurochemistry in a mouse model of neuropathic cancer pain[J].Pain,2005,(1/2):221-230.
  • 10SHIMOYAMA M,TANAKA K,HASUE F. A mouse model of neuropathic cancer pain[J].Pain,2002,(1/2):167-174.

二级参考文献38

  • 1项红兵,田玉科,孙怡.吗啡耐受形成过程中氯胺酮对小鼠脊髓诱导型一氧化氮合酶mRNA表达的影响[J].中华麻醉学杂志,2006,26(4):360-362. 被引量:4
  • 2Zhang Y, Li Y, Yang Y R, et al. Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain [J]. Neuroehem Res, 2007,32(9) :1592-1599.
  • 3Jacobson D A, Cho J, Landa L R, Jr, et al. Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression [J]. Am J Physiol Endoerinol Metab, 2006,291 (3) :E587-E595.
  • 4Cheng H Y, Laviolette S R, van der Kooy D, et al. DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine [J]. Eur J Neurosci, 2004,19( 11 ) : 3033-3041.
  • 5Cheng H Y, Pitcher G M, Laviolette S R. DREAM is a critical transcriptional repressor for pain modulation [J]. Cell, 2002,108( 1 ) : 31-43.
  • 6Cheng H Y, Penninger J M. DREAMing about arthritic pain [J]. Ann Rheum Dis, 2004,63 (Suppl 2) : ii72-ii75.
  • 7Buxbaum J D, Choi E K, Luo Y, et al. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment [J]. Nat Med, 1998,4(10) : 1177-1181.
  • 8Carrion A M, Link W A, Ledo F, et al. DREAM is a Ca^2+ -regulated transcriptional repressor [J].Nature, 1999,398 (6722) : 80-84.
  • 9Ledo F, Carrion A M, Link W A, et al. DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription [J]. Mol Cell Biol, 2000,20 (24) :9120-9126.
  • 10Ledo F, Link W A, Carrion A M, et al. The DREAM-DRE interaction: key nucleotides and dominant negative mutants [J]. Biochim Biophys Acta, 2000, 1498 (2-3) : 162-168.

共引文献7

同被引文献8

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部