冠心病患者C反应蛋白的临床意义及阿司匹林的影响

The clinical significance of C reactive protein in patients with coronary artery disease and the effect of aspirin on it

目的 :探讨 C反应蛋白 (CRP)与冠心病 (CHD)的关系及阿司匹林对其的影响。方法 :观察 6 9例冠状动脉单支狭窄 >6 0 %的 CHD患者 ,35例正常对照者及 31例病例对照者的 CRP浓度及不同剂量的阿司匹林对CRP浓度的影响 ,及 CRP浓度的高低与冠状动脉狭窄程度的关系。结果 :CHD患者的 CRP浓度较正常对照组显著增高 (P <0 .0 5 ) ,大剂量的阿司匹林可降低 CHD患者的 CRP浓度 (P <0 .0 5 ) ,CRP浓度与冠状动脉狭窄程度正相关 (r =0 .5 3,P <0 .0 5 )。结论

Objective:To explore the association between C reactive protein (CRP) and coronary artery disease.Method:CRP concentrations were examined in 69 patients with single vessel coronary artery disease (stenosis >60%),another 31 patients served for compare and 35 normal subjects as controls.The effect of different dosages of aspririn on CRP concentrations and the relation between CRP concentration and the degree of coronary artery stenosis were also studied.Result:CRP concentration in patients with coronary artery disease was significantly higher than that of the normal subjects (P< 0.05 ).CRP concentration in patients with coronary artery disease could be reduced with bigger dosage of aspirin(P< 0.05 ).There was a positive relation between the degree of coronary artery stenosis and CRP concentrations (r= 0.53 ,P< 0.05 ).Conclusion:CRP concentration may be used as an index for the evaluation of the severity of coronay artery disese.