三叶青提取物联合介入治疗兔VX2肝癌模型多层螺旋CT表现及肝功能动态分析

A Dynamic Analysis of Manifestation of the Multi-slice CT(MSCT) and Liver Function in Interventional Treatment of Rabbit VX2 Liver Cancer Model Combined with Tetrastigma Hemsleyanum Diels et.Gilg(SYQ) Extract

目的评价单纯介入治疗与三叶青提取物联合介入治疗兔VX2肝移植瘤的疗效。方法 33只荷瘤兔,随机分为空白对照组、单纯介入治疗组和三叶青提取物联合介入治疗组,14天后,对比分析其多层螺旋CT(MSCT)影像学改变及肝功能变化。结果三叶青提取物联合介入治疗在2周后MSCT检查显示肿瘤大小,肿瘤生长率、坏死率较单纯介入治疗及空白对照组疗效有统计学意义(P<0.05);在肝功能方面三叶青提取物联合介入治疗组GPT、GOT明显较其他两组降低,比较有统计学意义(P<0.05)。结论三叶青联合介入对VX2兔肝癌模型的介入治疗对肿瘤抑制及兔肝功能改变有一定疗效。

Objective To evaluate the effects of the interventional treatment combined with Tetrastigma hemsleyanum Diels et. Gilg （SYQ） extract on rabbit VX2 liver tumor. Methods Totally 33 tumor - bearing rabbits were randomly divided into 3 groups：control group, simple intervention group and intervention combined with SYQ extracts group. After 14 days, a comparative study of imaging ehan- ges of the multi - slice CT （MSCT） and liver function changes was carried out. Results After 14 days, imaging changes in the multi - slice CT （MSCT） showed that there was a significant effect in the tumor size, tumor growth rate, and necrosis rate by intervention combined with SYQ extracts group as compared with other two groups（ P 〈 0.05 ）. In intervention combined with SYQ extracts group, the positive rates of liver GPT, GOT were significantly lower than other two groups（P 〈 0.05）. Conclusion lnterventional treatment combined with SYQ extracts has a certain effect in inhibiting the VX2 rabbit liver tumor and maintaining a protective change in liver tunction.