运动血压变异性与蛋白尿、动脉硬化的关系

Exercise Blood Pressure Variability,Albuminuria,and Arterial Stiffness in Essential Hypertension

目的探讨原发性高血压患者运动血压变异性与尿蛋白、动脉硬化的关系。方法 50例健康人,男性女性各半,平均年龄64.5±5.1岁,作为对照组。高血压患者80例,平均年龄65.3±5.7岁,男性女性各半,作为高血压组。分别测运动血压与24h尿蛋白、踝臂动脉脉搏波传导速度(baPWV)。结果高血压组运动血压变异性明显大于对照组(P<0.05)。高血压组的24h尿蛋白含量、baPWV均大于对照组(P<0.05)。运动血压变异性与24h尿蛋白含量、baPWV均正相关(P<0.05)。结论运动血压变异性增大是高血压病的重要特征。运动血压变异性增大易导致动脉硬化及肾功能损害。

Objective To explore the relationship of exercise blood pressure variability with urinary albumin excretion and arterial stiffness in patients with essential hypertension. Methods Fifty normal persons 64.5 ± 5.1 years old were evenly divided by gender as control group. The study group 65.3 ± 5.7 years old consisted of eighty patients with essential hypertension. Exercise blood pressure was measured by treadmill exercise. 24 - hour urine protein was detected with Coomassie brilliant blue method, and arterial stiffness was evaluated on the basis of braehial - ankle pulse wave velocity. Results Patients with essential hypertension exhibited greater urine protein and higher pulse wave velocity and exercise blood pressure variability campared with those with normal pressure. In hypertensive group,excercise blood pressure variability was related to baPWV （ r = 0. 576, P 〈 0.01 ） and 24h - UPRO （ r = 0.510, P 〈 0.01 ）. In control group, excercise blood pressure variability was related to baPWV （ r = 0. 423, P 〈 0.01 ） and 24h - U PRO （ r = 0. 376, P 〈 0.05 ）. The correlativity of exercise blood pressure variability with baPWV and 24h - UPRO in the hypertensive group was greater than in the control group. Conclusion The increasing variability of exercise blood pressure is an important clinic character in hypertensions,which could induce the decrease of renal function and arterial stiffness at the early stage.