扁桃体组织中白细胞介素-4的表达和意义

The expression and effect of IL-4 in human palatine tonsil

目的 :为明确扁桃体反复发炎过程中 ,扁桃体组织中变态反应发生的情况。方法 :利用免疫组织化学的方法对扁桃体组织中白细胞介素 - 4(IL - 4)的表达情况进行测定。结果 :在各个年龄段的扁桃体组织中IL - 4均有高表达 ,IL - 4阳性细胞主要分布于扁桃体组织中的网状陷窝上皮和滤泡间区中 ,该部位是扁桃体的免疫功能区。结论 :IL - 4为一种与变态反应关系十分密切的细胞因子 ,扁桃体组织中有明显的变态反应发生 ,变态反应的存在为扁桃体反复发炎的病因之一 ,变态反应发生的部位主要在网状陷窝上皮和滤泡间区。

AIM: To study the allergic disease in recurrent tonsillitis. METHODS: Immunohistochemical technique was used to investigate interleukin-4(IL-4) production in tonsil. RESULTS:The result showed that: a higher incidence of IL-4 producing cells were found in the tonsils of all ages, and a high density of IL-4 was found in the reticular crypt epithelium and extrafollicular, but low density in germinalcenter. IL-4 has been shown play a crucial role in the pathogensis of allergic disease. CONCLUSION:Allergic disease is an important reason of recurrent tonsillitis. The conclusion will give a new way to cure recurrent tonsillitis.