奥施康定联合加巴喷丁应用于癌痛的疗效及对免疫功能影响的研究

Study on curative effects and impact on immune function of Oxycontin combined with Gabapentin in treatment for cancer pain

目的探讨奥施康定联合加巴喷丁应用于癌痛的疗效、安全性、成本及其对免疫功能的影响。方法将180例癌痛患者随机分为A、B、C三组，A、B、C组患者分别给予奥施康定、加巴喷丁、奥施康定联合加巴喷丁进行止痛治疗，比较三组患者治疗前后癌痛程度的改变、毒副反应、药物费用、生活质量和免疫功能各项指标。结果与治疗前相比，三组患者的癌痛均有不同程度的缓解，C组与A、B组相比，差异有显著性（P〈0．05）C组毒副作用明显轻于A、B组；C组患者人均花费529．42元，低于A组的646．06元，但高于B组的427．21元；三组患者治疗后均较治疗前生活项目的质量分数下降沪〈0．051，C组与A、B组相比，差异有显著性（P〈0．05）三组患者的免疫功能均有不同程度的改善，与治疗前相比，差异有显著性∽〈0．05）。结论采用奥施康定联合加巴喷丁能有效控制癌痛，减少副反应，减轻患者经济负担，提高患者的生活质量，改善患者的免疫功能。

Objective To study the efficacy, safety, cost and impact on immune function of Oxycontin combined with Gabapentin used in treating cancer pain. Methods 180 cases of cancer pain in our hospital were randomly divided into group A, B and C, patients of which were given Oxycontin, Gabapentin, Oxycontin combined with Gabapentin respectively for pain u^eatment, The analgesic effects, toxic reaction side effects, drug cost, quality of life, and immune function were all compared in three groups. Results The cancer pain control effect of patients in group C was significantly better than those in group A and B, having less adverse effect, improving immune function, and with less cost（P 〈 0.05）.Conclusion Application of Oxycontin combined with Gabapentin can effectively control cancer pain, reduce side effects and the financial burden of patients, improving patients＇ quality of life and their immune function.