阴道壁雌激素受体与压力性尿失禁以及盆腔器宫脱垂的关系研究

The discuss of relationship of vaginal wall estrogen receptors with stress urinary incontinence and pelvic organ prolapse

目的探讨阴道壁雌激素受体表达与压力性尿失禁以及盆腔器宫脱垂的关系。方法选择2009年10月-2011年10月在我院妇科采用免疫组化法检测绝经前后压力性尿失禁患者A组、盆腔器宫脱垂患者B组以及A＋B组患者阴道壁中雌激素受体（ER）阳性率，并选取同期因妇科良性疾病进行检查的患者作为对照组。结果与对照组比较，绝经前后三组患者的ER阳性表达率均明显降低，差异有显著性（P〈0．05），而阳性表达率三组之间两两比较，差异无显著性（P〉0．05）。结论绝经前后压力性尿失禁、盆腔器官脱垂患者阴道壁组织中雌激素受体的含量均明显降低，说明雌激素受体减少可能与压力性尿失禁、盆腔器官脱垂密切相关。

Objective To explore the relationship of vaginal wall estrogen receptor expression with stress urinary incontinence and pelvic organ prolapse. Methods From October 2009 to October 2011 in our hospital, we used IHCA to detect positive rate of vaginal wall estrogen receptors of patients with stress urinary incontinence（Group A）, patients with pelvic organ prolapse（Group B） and Group A ＋ B before and after menopause, and selected the same period patients received gynecological examination with benign diseases（control group）. Results Compared with control group, expression of ER-positive of 3 groups significantly decreased before and after menopause（P 〈 0.05）, while the positive expression rate of multiple comparison among 3 groups had no significant difference（P 〉 0.05）. Conclusions Vaginal wall estrogen receptor levels both significantly decrease in patients with stress urinary incontinence and pelvic organ prolapse before and after menopause. Which indicates that the reduction of estrogen receptors may be associated with stress urinary incontinence and pelvic organ prolapse closely.