克拉霉素联合甲硝唑及叶酸治疗49例萎缩性胃炎的临床效果分析

Clinical efficacy analysis on clarithromycin combined with mctronidazole and folic acid in treatment for 49 cases of chronic atrophic gastritis

目的探讨与分析克拉霉素联合甲硝唑及叶酸治疗萎缩性胃炎的临床疗效。方法选取2009年3月-2010年3月我院收治的98例萎缩性胃炎患者为研究对象，随机分为对照组与治疗组，对照组（49例）采用克拉霉素联合甲硝唑治疗，治疗组（49例）采用克拉霉素联合甲硝唑及叶酸治疗，比较两组患者治疗后的临床疗效。结果治疗组49例，显效26例，有效22例，无效1例，总有效率97．96％；对照组49例，显效15例，有效29例，无效5例，总有效率89．80％；两组临床疗效经比较差异有显著性（P〈0．05）。治疗组共5例出现不良反应，占10．20％。对照组共4例出现不良反应，占8．16％；两组不良反应的发生率经比较，差异无显著性（P〉0．05）。结论克拉霉素联合甲硝唑及叶酸治疗萎缩性胃炎具有较好的临床疗效，不良反应少，值得临床推广应用。

Objectives To explore and analyze the clinical effects of clarithromycin combined with metronidazole and folie acid in treatment for 49 cases of chronic acrnphic gastritis. Methods 98 cases of chronic atrophic gastritis received from March 2009 to March 2010 were randomly divided into two groups： control group and treatment group, 49 cases for each group. The control group was given clarithromycin and metronidazole for treatment, and the treatment group used clarithromycin combined with metronidazole and folio aeid. The clinical effect after treatment was compared in these two groups. Results As for the 49 cases of treatment group, 26 cases were significantly effective, 22 cases were effectual and 1 case was without effect, with a total effective rate of 97.96%; as for the control group, there were 15 significant effective cases, 29 cases effectual, and 5 with no effect respectively, and the total effective rate was 89.80%. There was statistical significant difference between the two groups （X 2 = 6.58, P 〈 0.05）. 5 cases in treatment group had adverse effects, accounting for 10.20%, while 4 cases in control group had adverse effect, taking up 8.16%. There was no significant difference in incidence between the two groups （P〉 0.05）. Conclusions The therapy of clarithromycin combined with metronidazole and folic acid has great effect in curing chronic atrophic gastritis, with less adverse effects and worthy of clinical application.