ELISA法检测血清EB病毒VCA-IgA对喉癌早期筛查的价值

Value of detection of serum Epstein-Barr virus VCA-IgA by ELISA technique for early diagnosis of laryngeal carcinoma

目的 评估血清检测EB病毒VCA-IgA对喉癌早期筛查的价值.方法 ELISA法检测喉癌患者48例、健康成人48例,血清EB病毒VCA-IgA.结果 喉癌患者组VCA-IgA阳性率为68.75%,而健康成人组VCA-IgA阳性率仅为2.08%.29例无颈淋巴结转移者与19例有颈淋巴结转移者之间,VCA-IgA阳性率无统计学差异.26例临床早期患者（Ⅰ期和Ⅱ期）和22例晚期患者（Ⅲ期和Ⅳ期之间）VCA-IgA阳性率亦无统计学差异.结论 ELISA法检测血清VCA-IgA有助于喉癌的早期筛查,但不能作为判断预后的指标.

Objective To evaluate the value of detection of serum Epstein - Ban＂ virus （EBV） VCA - IgA by ELISA technique for early diagnosis of laryngeal carcinoma. Methods Serum EBV VCA - IgA was detected by ELISA technique in 48 laryngeal carcinoma patients and 48 healthy aduhs. Results The positive rates of serum EBV VCA - IgA were 68.75 % of laryngeal carcinoma patients and 2.08% of healthy adults, respectively. The positive rate of serum EBV VCA - IgA in 29 patients without neck lymph node metastasis was not significant- ly different from that in 19 patients with neck lymph node metastasis. There was also no significant difference of positive rate of serum EBV VCA - IgA between 26 early stage patients（ stage I and II ） and 22 advanced stage patients （ stage m and IV ）. Conclusion The detection of serum EBV VCA - IgA by ELISA technique could be used as early diagnosis of laryngeal carcinoma, but not as an prognosis indicator.