调节性T细胞与恶性肿瘤的过继免疫治疗

Regulatory T Cells in adoptive cell therapy of cancer

过继免疫治疗利用自身免疫细胞进行体外扩增培养,然后回输到体内,它通过增强机体免疫力来对抗肿瘤,对肿瘤细胞具有靶向杀伤性作用,是最有可能彻底清除手术或放化疗后残存肿瘤细胞的治疗手段.但是,调节性T细胞（Regulatory T cells,Tregs）在多种恶性肿瘤患者外周血及微环境中普遍存在着比例上调的情况,这不仅会导致机体固有免疫的负性平衡,还会影响过继免疫治疗的疗效,使其不能发挥最大的抗肿瘤作用.通过对Tregs日渐深入的了解,人们已经研究出多种抑制及消除Tregs的治疗策略.

Adoptive cell therapy is the best treatment for patients with residual tumor cells after surgery, radiotherapy or chemotherapy, It is to culture immune cells in vitro for expansion and to ~einfuse into the patient to fight against and destruct cancer by enhancing the patient＇s immunity. However, the phenomenon of regulatory T cells（Tregs） was increased in peripheral blood, and tumor micro - environment of cancer patients is prevalence. These cells not only suppress the innate immunity,but also suppress the effect of adoptive cell therapy,which re- sult in no greatest anti - tumor effect. By further understanding of Tregs, people have developed a variety of treat- ment strategies to eliminate Tregs.