老年2型糖尿病患者血清超敏C反应蛋白与糖尿病肾病的相关性分析

目的探讨老年2型糖尿病患者血清超敏C反应蛋白与糖尿病肾病(DN)的相关性。方法将98例老年2型糖尿病患者依据尿白蛋白排泄率(UAER)分为:正常白蛋白尿组、微量白蛋白尿组和临床白蛋白尿组,另选同期健康体检者40例为健康对照组。采用免疫透射比浊法测定各组血清hsCRP浓度,比较各组间hsCRP水平。结果各组的hsCRP及血清Cr较对照组明显升高,并且呈现逐渐升高的趋势,差异具有统计学意义(P<0.05)。结论 hsCRP是DN的危险因素之一,监测其在患者体内的变化情况,对DN的早期发现和肾功能减退的预测有一定临床意义。

Objective To analyze the association between high-sensitive C-reactive proteinand diabetic nephropathy.Methods According to the results of urinary albumin excretion rate（UAER）,98 cases of T2DM were divided into normal albumin urinary group,micro albuminurinary group,and clinical albumin urinary group.Forty healthy subjects were enrolled as control.Theblood levels of hsCRP of all groups were measured.Results There was significant difference in hsCRP level between zhe groups and controlgroup.The level of hsCRP was increased with the increase of UAER,The difference was statistically significant（P0.05）.Conclusion hsCRP is one of the risk factors of DN,monitoring changes in the patient＇s body,DN,early detection of renal dysfunction predict certain clinical significance.