寄生性线虫半胱氨酸蛋白酶抑制剂研究进展

Research Progress on Cystatin of Parasitic Nematodes

半胱氨酸蛋白酶抑制剂(cysteine protease inhibitor,CPI或cystatin)是半胱氨酸蛋白酶可逆性紧密结合的天然抑制剂。寄生性线虫半胱氨酸蛋白酶抑制剂不仅具有独特的半胱氨酸蛋白酶抑制活性,而且还可以调节宿主免疫反应,在寄生虫逃避宿主免疫应答,适应寄生生活中起着重要作用。本文综述了半胱氨酸蛋白酶抑制剂的基本类型、结构特征和作用机制,以及寄生性线虫半胱氨酸蛋白酶抑制剂的研究进展。

Cystatins are reversibly tight-binding natural inhibitors of cysteine proteases.Cystatins in parasitic nematodes not only have the unique inhibition activity on cysteine proteases but also modulate the host immune response and have an important role in the immune evasion from host response and the adaptation to parasitism.This article reviews the classification,structure characteristics and function mechanism of cystatins,and the research progress on cystatins in parasitic nematodes.