Psoriasin在亚急性和慢性湿疹中的表达

The Expression and Significance of Psoriasin in Subacute and Chronic Eczema

目的研究Psoriasin(S100A7)蛋白在亚急性和慢性湿疹中的表达。方法用免疫组化SP法检测正常皮肤组织、亚急性和慢性湿疹皮损中Psoriasin蛋白的表达变化。结果 Psoriasin蛋白不表达于正常皮肤组织;在亚急性湿疹中,Psoriasin蛋白表达于角质层及棘层上1～5层,基底层无表达;在慢性湿疹中,可见Psoriasin蛋白表达于角质层及棘层全层,而不表达于基底层;在慢性湿疹和亚急性湿疹中,Psoriasin的水平均显著高于正常皮肤组织(P<0.05);Psoriasin蛋白水平在慢性湿疹中高于亚急性湿疹(P<0.05)。结论 Psoriasin可能参与慢性湿疹和亚急性湿疹的发病,且两者的炎症程度相关。

Objective To investigate the expression of psoriasin in subacute eczema and chronic eczema. Meth- otis Psoriasin protein expression in tissues of normal skin,subacute eczema and chronic eczema were de- tected by immunohistochemistry. Results There was no positive expression of psoriasin peotein in normal skin tissues,while psoriasin was expressed in stratum corneum and 1-5 stratum spinosum of subacute eczema,and it was expressed in stratum corneum and stratum spinosum but not stratum basale of chronic tissues. In addition,psoriasin expression was significantly higher both in chronic eczema and subacute eczema than that in normal tissues （P〈0.05）. Psoriasin expression was significantly higher in chronic eczema than that in subacute eczema （P 〈 0.05）. Conclusion Psoriasin may have a role in the pathogen- esis of subacute eczema and chronic eczema, and has a relationship with the level of inflammation.