慢性家族性良性天疱疮的共聚激光扫描显微镜的影像特征

Imaging Features of Chronic Familial benign Pemphigus by Confocal Laser Scanning Microscope

目的分析慢性家族性良性天疱疮患者皮损在共聚激光扫描显微镜(CLSM)下的影像特征。方法对入选患者的选定皮损处进行共聚激光扫描显微镜扫描,再取该处皮损进行组织病理检查,对这两者进行比较。结果皮损处的CLSM影像可见表皮棘层多处不规则断开或未完全断开,形成较多裂隙,棘层广泛松解,棘细胞间桥消失,但少数细胞间桥仍存在;因棘层松解而形成的腔隙中有单个或成团脱落的棘层松解细胞,基底细胞层有"绒毛"形成。结论慢性家族性良性天疱疮患者CLSM影像具有特征性表现,但该研究样本数有限,还需进一步研究论证。

Objective To analyse the characteristics of image by Confocal Laser Scanning Microscope （CLSM） of the familial benign chronic, pemphigus. Methods Select typical skin lesions of each patient and use Confocal Laser Scanning Microscope to scan.Further we examine by routine histology of the lesions. Finally,we compare the two results. Results In the scan images by the CLSM of the lesions, we can see many ir- regular cracks in the epidermis duo to prickle cell layer disconnected completely or incompletely, which is extensive acantholysis,and bridges between stratum stickle cells disappear,but the few remain; Because ofacantholysis, there are individual or a population of acantholytic cells in the cracks and＂villus＂ formation on the basal cell layer. Conclusion The features of images by CLSM of＇ the familial benign chronic pemphigus have its specificality, but due to the limited number, we need to further study its features.