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Sox9基因参与动物性别决定与分化的分子机制 被引量：1

Molecular Mechanisms of Sox9 Gene in Regulating Sex Determination and Differentiation of Animals
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摘要 Sox9基因参与动物多种生理活动的调控,其最主要的功能还是性别决定.笔者通过阅读大量文献,分析不同物种的性别决定分子机制,对Sox9参与动物的性别决定和分化进行了综述,为进一步研究Sox9基因在性别决定和分化中的作用提供参考. Sox9 gene can take part in many physiological activities of gene regulations.Its most important role is involved in sex determination.The molecular mechanisms of sex determination and differentiation regulated by Sox9 gene in different species are reviewed,which is expected to provide reference materials for further study on sex determination and differentiation of Sox9 gene.
作者 陈维 王昌留
机构地区 鲁东大学生命科学学院
出处 《鲁东大学学报（自然科学版）》 2012年第2期155-159,173,共6页 Journal of Ludong University:Natural Science Edition
基金 山东省自然科学基金(ZR2010CM030)
关键词 SOX9基因 性别决定 性别分化 分子机制 Sox9 sex determination sex differentiation molecular mechanism
分类号 Q343.1 [生物学—遗传学]
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参考文献39

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  • 2Meyer J,Südbeck P,Held M,et al.Mutational analy-sis of the SOX9gene in campomelic dysplasia and autosomal sex reversal:lack of genotype/phenotype correlations[J].Hum Mol Genet,1997,6(1):91-98.
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  • 5Barrionuevo F,Scherer G.SOX E genes:SOX9and SOX8in mammalian testis development[J].Int J Bi-ochemistry Cell Biol,2010,42(3):433-436.
  • 6Wada Y,Nishimura G,Nagai T,et al.Mutation anal-ysis of SOX9and single copy number variant analysis of the upstream region in eight patients with cam-pomelic dysplasia and acarrytomelic campomelic dys-plasia[J].Am J Med Genet A,2009,149A(12):2882-2885.
  • 7Lecointre C,Pichon O,Hamel A,et al.Familial acam-pomelic form of campomelic dysplasia caused by a 960kb deletion upstream of SOX9[J].Am J Med Genet A,2010,149A(6):1183-1189.
  • 8Im G-l,Kim H-J,Lee J H.Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio(SOX-5,-6 and-9)genes[J].Biomaterials,2011,32(19):4385-4392.
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二级参考文献237

共引文献75

同被引文献12

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鲁东大学学报（自然科学版）
2012年 第2期

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