心房纤颤患者血清sCD40L及hs-CRP的动态变化

Dynamic changes of soluble sCD40 Ligand and hyper-sensitivity C-reactive protein in Patients with atrial fibrillation

目的动态观察心房纤颤(AF)患者血清可溶性CD40配体(sCD40L)及超敏C-反应蛋白(hs-CRP)的变化,探讨其临床意义。方法选取43例AF患者及20例对照,用ELISA法检测血清sCD40L水平,采用免疫透射比浊法检测血清hs-CRP水平;AF患者接受射频消融术,动态观察术前及术后0、12、24 h研究指标的变化。结果①与射频消融术前相比,sCD40L、hs-CRP在术后0、12、24 h均明显降低(P<0.05);射频消融术后0、12、24 h 3组间相互比较,sCD40L及hs-CRP随术后时间的延长而呈下降趋势,但水平差异无统计学意义(P>0.05);②对照组sCD40L及hs-CRP水平低于AF组,2组差异有统计学意义(P<0.05)。结论检测sCD40L及hs-CRP对临床AF治疗具有一定的指导意义,炎症机制可能在AF的发生发展过程中发挥作用。

Objective To observe the dynamic changes of soluble CD40 ligand（sCD40L）concentration and hyper-sensitivity C-reactive protein（hs-CRP）in patients with atrial fibrillation（AF）,to explore the clinical significance.Methods 43 patients with AF and 20 controls included in the research,ELISA and immunoturbidimetric assay was used to test the serum concentration of sCD40L and hs-CRP,respectively.The circulating concentrations of sCD40L and hs-CRP were prospectively measured（both pre-procedure,and 0h,12h and 24h after the procedure）in 43 AF undergoing catheter radiofrequency ablation.Results The serum concentration of sCD40L and hs-CRP were significantly higher pre-procedure in study patients（P0.05）.The two inflammatory markers gradually decreased among the three groups after CRA,while there was no statistical significance（P0.05）.The serum concentration of sCD40L and hs-CRP in controls was lower than that in AF（P0.05）.Conclusion It is useful to test sCD40L and hs-CRP for treatment in patients with AF,inflammatory mechanisms may play an important role in the development of AF.