676株铜绿假单胞菌的分布及耐药性

Distribution and drug resistance of 676 Strains of Pseudomonas aeruginosa

目的探讨铜绿假单胞菌临床分离株的分布及耐药特征,为临床合理使用抗菌药物提供依据。方法回顾性地对医院2007年1月至2011年12月临床分离的676株铜绿假单胞菌的临床分布及药敏结果进行分析。结果 676株铜绿假单胞菌临床分布比较广泛,呼吸内科(26%)、老干部病房(17.6%)、ICU(10.7%)的患者感染率较高。感染部位以呼吸道为主,占78.1%。5年来铜绿假单胞菌对复方新诺明的耐药率最高(约80%);对亚胺培南的耐药率最低,保持在10%以下;对其他10种抗菌药物的耐药率有上升趋势。结论铜绿假单胞菌是临床常见的致病菌,我们应继续加强对铜绿假单胞菌耐药性的监测,指导临床合理使用抗生素,控制耐药菌株的扩散。

Objective To investigate the distribution and drug resistance of Pseudomonas aeruginosa（PAE）,and to provide basis for the use of drugs in clinic.Methods The distribution and drug resistance of 676 strains of PAE isolated clinically from Jan.2007 to Dec.2011 was retrospectively analyzed.Results The 676 strains of PAE distributed extensively in clinic.The infection rate of PAE was found to be higher in the Departmetn of Respiratory Medicine（26%）,Old Cadre Ward（17.6%） and ICU（10.7%） than in other departments.The main infected site was respiratory tract,accounting for 78.1%.During the last 5 years,the drug resistance rate of to SXT was the highest（about 80%）,and that to imipenem was the lowest（remaining below 10%）.The drug resistance of PAE to other 10 kinds of drugs showed a rising trend.Conclusion PAE is a common pathogenic bacteria in clinic.We should strengthen the monitoring of its drug resistance to provide guidance for reasonable use of antibiotics and rational control of drug-resistant strains.