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丙型肝炎病毒感染对肝细胞信号传导通路的影响及研究进展

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摘要 丙型肝炎病毒(HCV)是一种嗜肝RNA病毒,主要引起肝功能损害,可发展为肝纤维化、肝硬化甚至肝癌。该病可分为急性和慢性,慢性感染治疗方式较为局限,治疗无应答时有出现,迄今为止无特异性疫苗,故其危害较大。丙型肝炎的感染机制尚未明确,本文从HCVRNA的基本结构入手,分析了病毒各部分在感染中的作用、HCV感染后细胞信号传导通路的变化,并陈述了干扰素抗病毒的可能机制。
作者 高艺 龚环宇
出处 《海南医学》 CAS 2012年第10期116-119,共4页 Hainan Medical Journal
关键词 HCV 肝炎 干扰素
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